Effekt of Antiparkinson Drug HP-200 (Mucuna pruriens) on the Central Monoaminergic Neurotransmitters.

Bala V. Manyam, Muralikrishnan Dhanasekaran, Theodore A. Hare

HP-200, which contains Mucuna pruriens endocarp, has been shown to be effective in the treatment of Parkinson's disease. Mucuna pruriens endocarp has also been shown to be more effective compared to synthetic levodopa in an animal model of Parkinson's disease. The failure of Mucuna pruriens endocarp to significantly affect dopamine metabolism in the striatonigral tract along with its ability to improve Parkinsonian symptoms in the 6-hydroxydopamine animal model and humans may suggest that its antiparkinson effect may be due to components other than levodopa or that it has a levodopa enhancing effect.

Phytother. Res. 18, 97-101 (2004)


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